Our lab is currently studying:
1. Normal and defective erythropoiesis, using human samples as well as murine models of human red blood cell disorders. |
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2. The pathophysiology of the congenital dyserythropoietic anemias (using in vitro and in vivo studies). |
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3. The transport of proteins from the endoplasmic reticulum to the Golgi apparatus, and how defects in this pathway result in human disease. |
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4. Rare hereditary hematologic disorders, with the goal of identifying the genetic defects underlying these diseases, followed by the study of the pathogenesis of these disorders through in vitro and in vivo studies. |
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Our lab employs a wide variety of scientific techniques, including mouse genetics, CRISPR/Cas9 targeted gene editing and CRISPR-Cas9 genome wide screens, bone marrow transplantation experiments, flow cytometry, and various cell and molecular biology techniques.
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